Determination of the Gas-phase Acidities of Oligopeptides

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Determination of the gas-phase acidities of oligopeptides.

Amino acid residues located at different positions in folded proteins often exhibit different degrees of acidities. For example, a cysteine residue located at or near the N-terminus of a helix is often more acidic than that at or near the C-terminus (1-6). Although extensive experimental studies on the acid-base properties of peptides have been carried out in the condensed phase, in particular ...

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ژورنال

عنوان ژورنال: Journal of Visualized Experiments

سال: 2013

ISSN: 1940-087X

DOI: 10.3791/4348